Anti-EXOSC7 Polyclonal Antibody for WB, ELISA - Q15024

Core Product Specifications and Parameters

Biological Background: EXOSC7 Function and Localization

• EXOSC7, also known as RRP42, p8, or EAP1, is a non-catalytic component of the RNA exosome complex, a multi-subunit machinery with 3'→5' exoribonuclease activity.
• The RNA exosome participates in diverse nuclear RNA processing events, including maturation of rRNA, snRNA, and snoRNA, and in the elimination of processing by-products and pervasive non-coding transcripts such as antisense RNA and PROMPTs.
• In the cytoplasm, the complex is involved in general mRNA turnover, degradation of ARE-containing unstable mRNAs, and surveillance pathways that prevent translation of aberrant mRNAs, including histone mRNAs.
• EXOSC7 and the exosome complex are implicated in immunoglobulin class switch recombination and somatic hypermutation, likely by targeting AICDA deamination activity to transcribed dsDNA.
• The protein localizes to the nucleus, nucleolus, and cytoplasm, consistent with its roles in both nuclear RNA processing and cytoplasmic mRNA decay.
• Post-translational modifications include acetylation and phosphorylation, and it contains RNA-binding capacity, reflecting its function within the exosome scaffold.

Experimental Guidance and Technical Tips

• The immunogen used to generate this polyclonal antibody covers nearly the full-length EXOSC7 protein (aa 1–291), which may provide broad epitope recognition.
• For Western blotting, the expected molecular weight of endogenous EXOSC7 is approximately 32 kDa; consider using appropriate loading controls and verifying specificity with knockout or knockdown lysates if available.
• When performing ELISA, the antibody can serve as a capture or detection reagent, but optimal dilutions and conditions should be empirically determined for your specific assay format.
• Cross-reactivity with mouse and rat orthologs is reported; confirm performance in your target species using a relevant positive control.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your one-stop sourcing partner for IVD raw materials, offering a streamlined bridge from research to clinical application. This EXOSC7 antibody supports research in RNA biology and exosome-related pathways, and CamelBio can further supply validated antibody pairs, optimized monoclonal or polyclonal antibodies, bulk ancillary reagents, and assist with sourcing rare-target raw materials to accelerate your diagnostic development.