Anti-EXOSC10 Polyclonal Antibody for WB and ELISA - Q01780

Core Product Specifications and Parameters

Biological Background: EXOSC10 Function and Localization

• Catalytic component of the RNA exosome complex, providing 3'->5' exoribonuclease activity for RNA processing and degradation, including rRNA, snRNA, snoRNA maturation and elimination of pervasive transcripts.
• Involved in the SSU processome for pre-rRNA processing and targeted degradation during ribosome biogenesis. Related references: PMID:34516797
• Required for DNA double-strand break repair by homologous recombination: recruits RPA and RAD51, and regulates damage-induced RNAs to limit end resection. Related references: PMID:25632158 PMID:31086179
• Essential for global protein translation and cell proliferation. Related references: PMID:26857222 PMID:36912080
• Regulates metabolism of C9orf72-derived repeat RNA, preventing translation into toxic dipeptide repeat proteins. Related references: PMID:32830871
• Localizes to the cytoplasm and nucleus (nucleolus and nucleoplasm). Undergoes alternative splicing, phosphorylation, and Ubl conjugation.

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 586–885 of human EXOSC10, targeting the C-terminal region. Consider designing experiments with this region in mind for epitope masking or competition assays.
• For Western blot, the predicted molecular weight is approximately 101 kDa. Verify band size in your sample system; post-translational modifications may affect migration.
• The antibody is applicable to human, mouse, and rat samples by WB and ELISA. Validate in your specific model, as expression levels may vary.
• As a polyclonal antibody, lot‑to‑lot variability may occur. It is recommended to test each new lot in your assay system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and research teams with a complete range of IVD raw materials, from monoclonal and polyclonal antibodies to ancillary reagents. For EXOSC10 studies, we offer validated antibody pairs and bulk sourcing options to streamline your assay development. Our team also specializes in sourcing rare‑target raw materials, ensuring you have the components needed from concept to clinic.