Anti-ESRRG Rabbit Monoclonal Antibody for WB, ELISA - P62508

Core Product Specifications and Parameters

Biological Background: ESRRG Function and Localization

• Estrogen-related receptor gamma (ESRRG) is an orphan nuclear receptor that functions as a transcription activator in the absence of ligand.
• It binds specifically to estrogen response elements (EREs) and activates transcription of ERE-controlled reporter genes.
• In skeletal muscle, ESRRG induces the expression of PERM1, a regulator of mitochondrial biogenesis and oxidative metabolism.
• Primarily localized in the nucleus, consistent with its role in transcriptional regulation.
• Expressed in multiple tissues including heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord, and thyroid gland.
• Contains zinc-finger DNA-binding domains and is subject to post-translational modifications including acetylation and phosphorylation.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (amino acids 1–100) of human ESRRG. This region may be conserved across species, supporting the observed cross-reactivity with mouse and rat.
• For Western blotting, expect a band at approximately 51 kDa. Use tissue lysates from heart or skeletal muscle as positive controls, where ESRRG expression is well documented.
• For ELISA, consider optimizing antibody dilution and buffer conditions; indirect or sandwich ELISA formats may be suitable depending on the assay design.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a one-stop supply chain for IVD raw materials, supporting diagnostic manufacturers and research laboratories from concept to clinic. Whether you need validated antibody pairs, optimized monoclonal or polyclonal antibodies, bulk ancillary reagents, or rare target raw-material sourcing, CamelBio streamlines the procurement process. For nuclear receptor targets like ESRRG, our global sourcing network and technical expertise help you accelerate assay development with confidence.