Anti-ESD (Esterase D) Rabbit Polyclonal Antibody for WB, IHC-P, ELISA - P10768

Core Product Specifications and Parameters

Biological Background: ESD Function and Localization

• ESD (Esterase D/S-formylglutathione hydrolase) is a serine hydrolase encoded by the ESD gene (GeneID: 2098).
• The primary function of ESD is the detoxification of formaldehyde, catalyzing the hydrolysis of S-formylglutathione to formic acid and glutathione.
• Alternative names include methylumbelliferyl-acetate deacetylase, reflecting its ability to hydrolyze certain ester substrates.
• Subcellularly, ESD is localized to the cytoplasm and is also found associated with cytoplasmic vesicles.
• Post-translational modification includes acetylation, as identified by proteomics approaches.
• A 3D structure of ESD has been solved, and the mature protein has a calculated molecular mass of approximately 31.5 kDa.

Experimental Guidance and Technical Tips

• The antibody is raised against recombinant full-length human ESD (amino acids 1–282). For Western blot, expect a band near 31 kDa; a 10–12% SDS-PAGE gel is recommended for optimal separation.
• For IHC-P, consider optimizing antigen retrieval conditions in positive control tissues that express ESD.
• ELISA performance may vary with coating antigen; using the immunogen or purified native ESD is advisable for capture or detection formats.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with streamlined access to high-quality IVD raw materials like this anti-ESD polyclonal antibody. Our portfolio includes validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and sourcing support for rare targets. Whether you are developing assays for formaldehyde metabolism or other research areas, CamelBio’s integrated supply chain and technical guidance help bridge the gap from concept to clinic.