Anti-ERG Rabbit Polyclonal Antibody for WB, ELISA - P11308

Core Product Specifications and Parameters

Biological Background: ERG Function and Localization

• ERG (ETS-related gene) encodes a transcriptional regulator protein, also referred to as Transforming protein ERG.
• It may participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase, leading to modification of local chromatin structure.
• Subcellular localization includes both the nucleus and cytoplasm.
• Classified as a DNA-binding protein and proto-oncogene, ERG is frequently involved in chromosomal rearrangements associated with oncogenesis.
• The gene undergoes alternative splicing, producing multiple protein isoforms.
• Post-translational modifications include phosphorylation and ubiquitination (Ubl conjugation).
• The predicted molecular weight is approximately 54 kDa (UniProt: 53.8 kDa).

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 1–280 (N-terminal region) and may detect multiple isoforms if this region is conserved; verify isoform specificity in your system.
• For Western blot, a band near 54 kDa is expected; include appropriate positive and negative controls to confirm specificity.
• For ELISA, consider whether the antibody recognizes the native conformation and optimize conditions accordingly.
• Cross-reactivity is documented for human; validation in other species should be performed before use.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a streamlined supply chain for IVD raw materials, featuring validated antibodies like this anti-ERG polyclonal antibody for research in transcriptional regulation and oncology. Our portfolio includes optimized monoclonal and polyclonal antibodies, antibody pairs, bulk ancillary reagents, and sourcing for rare targets to accelerate your diagnostic development from concept to clinic.