Monoclonal Antibodies
Anti-ErbB3/HER3 Monoclonal Antibody (, Rabbit) for Flow Cytometry - P21860
Item Number : CM0007754
Price varies based on specs and customizations
- Application
- FC
- Cross Reactivity
- Human
- Protein Weight
- 148kDa
Shipping:
Contact us to get shipping details Enjoy On-time Dispatch Guarantee.
Why Choose Us
Easy ordering process, quality products, and dedicated support for your business success.
Core Product Specifications and Parameters
| Parameter | Value |
|---|---|
| Product Name | Rabbit anti-Human ErbB3/HER3 mAb |
| Remarks/Alias | HER3; FERLK; LCCS2; VSCN1; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3 |
| Species | Human |
| GeneID (human) | 2065 |
| GeneID | 2065 |
| Immunogen | Recombinant protein|Recombinant fusion protein containing a sequence corresponding to amino acids 20-643 of human ErbB3/HER3 (NP_001973.2). |
| Source | Rabbit |
| Category | Monoclonal Antibodies |
| Application | FC |
| Cross Reactivity | Human |
| SWISS | P21860 |
| Protein Weight | 148kDa |
| Shipping | Ice bag |
Biological Background: ErbB3/HER3 Function and Localization
- HER3 is a receptor tyrosine-protein kinase that serves as a receptor for neuregulins, especially NRG1, and is activated upon ligand binding.
- Ligand binding induces phosphorylation on tyrosine residues and promotes association with the p85 subunit of phosphatidylinositol 3-kinase (PI3K). Related references: PMID:20682778
- HER3 may also be activated by chondroitin sulfate proteoglycan 5 (CSPG5). Related references: PMID:15358134
- It is involved in the regulation of myeloid cell differentiation. Related references: PMID:27416908
- Subcellularly, HER3 is located at the cell membrane and can also be secreted.
- It is expressed in epithelial tissues and brain.
- Keywords indicate it is a glycoprotein, phosphoprotein, kinase, and disulfide-bonded receptor.
Experimental Guidance and Technical Tips
- The immunogen comprises the extracellular domain (amino acids 20–643), suggesting the antibody likely recognizes an extracellular epitope, making it suitable for live-cell surface staining in flow cytometry without permeabilization.
- For intracellular detection of HER3, consider fixing and permeabilizing cells prior to staining.
- Titrate the antibody to determine the optimal concentration for your specific cell type and experimental conditions.
- Include appropriate isotype controls and use HER3-positive and -negative cell lines to validate staining specificity.
CamelBio: Your One-Stop Sourcing Bridge
CamelBio is your comprehensive partner for IVD raw material sourcing, offering reliable antibodies, recombinant proteins, and ancillary reagents to support oncology and signaling research. This anti-ErbB3/HER3 antibody is suitable for flow cytometry applications, and we can assist with complementary product sourcing such as detection antibodies, assay buffers, and bulk orders. Contact us to explore tailored solutions that accelerate your diagnostic development.
Product Datasheet
Anti-ErbB3/HER3 Monoclonal Antibody (, Rabbit) for Flow Cytometry - P21860
REQUEST A QUOTE
Our professional team will reply to you within one business day. Please feel free to contact us!