Anti-DYNLL2 Rabbit Polyclonal Antibody for WB, IF/ICC, ELISA - Q96FJ2

Core Product Specifications and Parameters

Biological Background: DYNLL2 Function and Localization

• DYNLL2 encodes dynein light chain 2, cytoplasmic, also known as 8 kDa dynein light chain b (DLC8b) or dynein light chain LC8-type 2.
• Acts as a non-catalytic accessory component of the cytoplasmic dynein 1 complex, linking dynein to cargos and adapter proteins that regulate dynein function.
• Cytoplasmic dynein 1 functions as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
• May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
• Subcellular localization: cytoplasm, cytoskeleton.
• Annotated with keywords: 3D-structure, dynein, microtubule, motor protein, transport, and reference proteome.

Experimental Guidance and Technical Tips

• The immunogen covers the full-length human DYNLL2 protein (residues 1-89); consider this when designing detection and blocking strategies for native versus denatured epitopes.
• For WB, verify a band at approximately 10 kDa under reducing conditions, and optimize the antibody dilution in your sample system.
• For IF/ICC, expect cytoplasmic and cytoskeletal staining; validate fixation and permeabilization protocols to preserve target localization.
• For ELISA, use as a capture or detection reagent after confirming specificity against the target protein.
• Cross-reactivity with mouse and rat DYNLL2 is reported; validate performance in each species as needed.

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