Anti-DYNC1I2 Polyclonal Antibody for WB, ELISA - Q13409

Core Product Specifications and Parameters

Biological Background: DYNC1I2 Function and Localization

• DYNC1I2 (Cytoplasmic dynein 1 intermediate chain 2) is a non-catalytic accessory subunit of the cytoplasmic dynein 1 motor complex, essential for linking dynein to cargos and adapter proteins (PubMed:31079899).
  Related references:
  PMID:31079899
• Functions as a microtubule minus-end-directed motor for retrograde intracellular transport of vesicles and organelles (PubMed:31079899).
  Related references:
  PMID:31079899
• Mediates binding of dynein to dynactin via the p150-glued subunit DCTN1, and is involved in trafficking of Golgi, late endosomes, and lysosomes.
• Localizes to the cytoplasm and associates with the cytoskeleton.
• Subject to post-translational modifications including acetylation and phosphorylation; mutations are associated with intellectual disability (NEDMIBA).
• Contains WD repeat domains that facilitate protein-protein interactions, and alternative splicing generates multiple isoforms.
• Plays a role in host-virus interactions.

Experimental Guidance and Technical Tips

• The immunogen consists of a recombinant fusion protein spanning amino acids 352–612 of human DYNC1I2. For endogenous detection in WB, consider using whole-cell lysates of human, mouse, or rat origin.
• As a polyclonal antibody, it may recognize multiple isoforms or post-translationally modified forms; validate specificity in the relevant experimental system.
• For ELISA applications, optimize coating antigen and antibody dilution empirically.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a comprehensive sourcing platform for IVD raw materials, including validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare target procurement. For dynein motor protein research and diagnostic development, we offer reliable access to DYNC1I2-targeting reagents supported by scientific expertise. Partner with CamelBio to streamline your supply chain from concept to clinic.