Anti-Dynamin 3 Polyclonal Antibody for WB, IF/ICC, ELISA - Q9UQ16

Core Product Specifications and Parameters

Biological Background: Dynamin 3 Function and Localization

• Dynamin-3 is a microtubule-associated motor protein that binds and hydrolyzes GTP, driving the formation of microtubule bundles. (By similarity)
• It is implicated in vesicular trafficking, most likely mediating endocytosis. (By similarity)
• The protein localizes to the cytoplasm and associates with the cytoskeleton, supporting its role in membrane remodeling and transport.
• Alternative splicing produces multiple isoforms, including a testicular-specific variant known as T-dynamin.
• Post-translational modifications such as acetylation and phosphorylation may regulate its activity.
• It belongs to the dynamin family of large GTPases, characterized by their role in membrane scission and cytoskeletal interactions.

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 410–555, a region that may be conserved across species; cross-reactivity with mouse and rat has been observed.
• For Western blot, consider a molecular weight around 98 kDa; note that isoform variations may result in additional bands.
• Validate the antibody in your specific sample matrix, as endogenous dynamin-3 expression levels can vary between cell types.
• For immunofluorescence, permeabilization and fixation conditions should be optimized for microtubule-associated proteins.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with validated antibody pairs, optimized polyclonal antibodies, and bulk ancillary reagents for IVD development. For targets such as Dynamin 3, which plays a role in endocytosis and membrane trafficking, CamelBio can assist in sourcing rare-target raw materials and offering technical consultation. Partner with us to streamline your supply chain from concept to clinical application.