Anti-DVL3 Polyclonal Antibody for WB, IHC-P, ELISA - Q92997

Core Product Specifications and Parameters

Biological Background: DVL3 Function and Localization

• DVL3 (Dishevelled 3) is a segment polarity protein and homolog of Drosophila dishevelled, also designated DSH homolog 3.
• It functions as a key cytoplasmic mediator in the canonical and non-canonical Wnt signaling pathways.
• Localizes predominantly in the cytoplasm.
• Classified as a developmental protein due to its roles in embryogenesis and tissue patterning.
• Subject to post-translational modifications including phosphorylation and methylation, and regulated by ubiquitination.
• Alternative splicing produces multiple isoforms, contributing to functional diversity.
• Mutations or dysregulation of DVL3 have been associated with developmental disorders such as dwarfism.
• High-resolution structural information is available (3D-structure).

Experimental Guidance and Technical Tips

• The immunogen covers the C-terminal region (amino acids 580–650) of human DVL3, which may confer specificity toward certain isoforms; validate reactivity in your sample system.
• For Western blotting, the expected band is approximately 78 kDa; consider using appropriate molecular weight markers and positive controls.
• In immunohistochemistry (IHC-P), optimize antigen retrieval and antibody dilution, and validate staining in relevant tissue sections.
• For ELISA, the polyclonal nature provides sensitive detection; pair with a matched antibody if designing a sandwich assay.
• Cross-reacts with human, mouse, and rat DVL3 as indicated; however, verify performance if using other species.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This DVL3 polyclonal antibody supports research into Wnt signaling and developmental biology. Whether you need validated antibody pairs, bulk ancillary reagents, or rare target raw materials for your assay development, CamelBio bridges your sourcing needs efficiently.