Anti-DVL1 Polyclonal Antibody for WB, ELISA - O14640

Core Product Specifications and Parameters

Biological Background: DVL1 Function and Localization

• DVL1 is segment polarity protein dishevelled homolog 1, also known as DSH homolog 1, encoded by the DVL1 gene.
• It participates in Wnt signaling by binding to the cytoplasmic C-terminus of Frizzled receptors and transducing signals to downstream effectors, playing roles in both canonical and non-canonical pathways.
• DVL1 is required for LEF1 activation upon WNT1 and WNT3A signaling, and it forms a ternary complex with PAK1 and MUSK important for acetylcholine receptor clustering at the neuromuscular junction.
• The protein localizes to the cell membrane, cytoplasm, cytosol, and cytoplasmic vesicles.
• It is a phosphoprotein subject to ubiquitin conjugation, and alternative splicing generates isoforms.
• Keywords classify DVL1 as a developmental protein and reference proteome, with implications in dwarfism, indicating potential roles in skeletal development.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide spanning amino acids 11-110 of human DVL1, suggesting the antibody primarily recognizes the N-terminal region of the protein.
• For Western blot, the predicted molecular weight is approximately 75 kDa; validate band specificity with appropriate positive and negative controls in the relevant sample system.
• For ELISA, consider using the antibody for detection or capture, but optimization of coating concentration and blocking conditions may be necessary.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with comprehensive access to IVD raw materials, covering all stages from concept to clinic. For DVL1-related research in Wnt signaling and developmental biology, we offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents to support your assay development. Our robust supply chain also facilitates sourcing of rare target raw materials to accelerate your projects.