Anti-DRG2 Rabbit Polyclonal Antibody for WB, IF/ICC, ELISA - P55039

Core Product Specifications and Parameters

Biological Background: DRG2 Function and Localization

• Protein Identity: DRG2 (Developmentally-regulated GTP-binding protein 2) is also known as Translation factor GTPase DRG2 or TRAFAC GTPase DRG2. It belongs to the DRG family of GTP-binding proteins.
• Core Function: DRG2 catalyzes the conversion of GTP to GDP, functioning as a hydrolase. When hydroxylated at Lys-21 by JMJD7, it may bind RNA and participate in translation regulation.
• Subcellular Localization: DRG2 is localized to both the nucleus and the cytoplasm, consistent with roles in nuclear and cytoplasmic processes.
• Tissue Distribution: DRG2 is expressed at highest levels in skeletal muscle, heart, and kidney, with lower levels in colon, thymus, spleen, small intestine, lung, and leukocytes.
• Keywords and Modifications: The protein is classified as a GTP-binding, nucleotide-binding hydrolase that requires magnesium as a cofactor. It is subject to hydroxylation and Ubl conjugation, and has been identified in proteomics studies.

Experimental Guidance and Technical Tips

• Immunogen Background: The immunogen is a recombinant fusion protein covering amino acids 150-260 of human DRG2 (NP_001379.1). This region lies within the GTPase domain and may be conserved across species, consistent with the reported human, mouse, and rat reactivity.
• Application Notes: The antibody is suitable for Western blotting, immunofluorescence/immunocytochemistry, and ELISA. For each application, we recommend validating the antibody in the relevant sample system and optimizing detection parameters (e.g., dilution, incubation time) based on endogenous expression levels.
• Cross-Reactivity Considerations: The antibody detects DRG2 from human, mouse, and rat. Cross-reactivity with other species or related DRG family members (e.g., DRG1) should be experimentally verified.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive one-stop sourcing platform for IVD raw materials, supporting developers from concept to clinic. This DRG2 polyclonal antibody serves researchers exploring GTPase signaling and translational control. Alongside validated antibodies, CamelBio provides tailored sourcing for bulk ancillary reagents, rare-target raw materials, and custom antibody development to streamline your diagnostic assay pipelines.