Anti-DR1 Rabbit Polyclonal Antibody for WB and ELISA - Q01658

Core Product Specifications and Parameters

Biological Background: DR1 Function and Localization

• Protein Dr1, also known as down-regulator of transcription 1, negative cofactor 2-beta (NC2-beta), and TATA-binding protein-associated phosphoprotein, functions as a transcriptional repressor.
• Forms a stable heterodimer with DRAP1 to repress both activated and basal transcription of class II genes by binding the TATA-binding protein (TBP) and preventing the association of TFIIA and/or TFIIB.
• Exhibits intrinsic DNA-binding capability independent of its partner DRAP1.
• Component of the ATAC complex, which possesses histone acetyltransferase activity targeting histones H3 and H4, linking it to chromatin modification.
• Localizes predominantly to the nucleus, consistent with its role in transcription regulation.
• Subject to post-translational modifications including acetylation and phosphorylation, which may modulate its repressor function.
• Identified as a DNA-binding, nuclear phosphoprotein involved in transcription regulation, with known 3D structures.

Experimental Guidance and Technical Tips

• The immunogen comprises the full-length DR1 protein (amino acids 1-176), enabling potential recognition of both native and denatured forms. For WB, consider standard denaturing conditions and validate in your specific sample system.
• For ELISA, ensure coating antigen matches the immunogen sequence to maximize signal. Include appropriate positive and negative controls.
• The antibody demonstrates cross-reactivity with mouse and rat DR1; verify specificity and performance in your experimental model.
• As a polyclonal antibody, lot-to-lot consistency should be confirmed for critical applications.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to validated antibody pairs, optimized polyclonals, and ancillary reagents to streamline IVD development. This anti-DR1 antibody adds to our portfolio for transcription regulation targets, supporting your research and assay design needs. From bulk raw materials to rare target sourcing, we bridge the gap from concept to clinic.