Anti-DNAL4 Rabbit Polyclonal Antibody for WB, ELISA - O96015

Core Product Specifications and Parameters

Biological Background: DNAL4 Function and Localization

• DNAL4 encodes dynein axonemal light chain 4, a component of the outer dynein arm in motile cilia.
• It functions as a force-generating motor protein, producing microtubule minus-end-directed movement essential for ciliary beating.
• The protein possesses ATPase activity to power conformational changes associated with dynein stepping.
• Subcellularly, DNAL4 localizes to the cytoplasm and specifically to the axoneme of motile cilia.
• As a dynein light chain, it contributes to the structural and regulatory integrity of the dynein complex.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N‑terminal region (amino acids 1–105) of human DNAL4, which may be conserved across species; consistent with the observed mouse and rat cross‑reactivity.
• For Western blot, consider using reduced/denatured samples from human, mouse, or rat tissues rich in motile cilia (e.g., trachea, lung). Expect a band near 12 kDa.
• As a polyclonal antibody, it may detect multiple isoforms or post-translationally modified forms; validate specificity in the relevant experimental system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with streamlined access to validated IVD raw materials, including antibodies against dynein and ciliary proteins. Our sourcing network supports bulk procurement of polyclonal antibodies, ancillary reagents, and custom services to accelerate your cilia and motor protein research from concept to clinic.