Anti-DNA Polymerase gamma Rabbit Polyclonal Antibody for WB, ELISA - P54098

Core Product Specifications and Parameters

Biological Background: DNA Polymerase gamma Function and Localization

• DNA Polymerase gamma is the catalytic subunit of the mitochondrial DNA polymerase, responsible for the replication of mitochondrial DNA (mtDNA). It replicates both heavy and light strands using single-stranded DNA templates and RNA primers. Related references: PMID:11477093, PMID:11897778, PMID:15917273
• Possesses 5'->3' DNA polymerase activity and 3'->5' exonucleolytic proofreading activity, ensuring high fidelity during mtDNA synthesis. It proficiently corrects base substitutions, single-base additions, and deletions. Related references: PMID:10827171, PMID:11477094, PMID:11504725
• Forms a highly processive replisome with the mitochondrial helicase TWNK and single-stranded DNA-binding protein SSBP1 at the replication fork. Related references: PMID:11477093, PMID:11897778, PMID:15167897
• Exhibits 5'-deoxyribose phosphate (dRP) lyase activity, mediating repair-associated mtDNA synthesis in the base-excision repair pathway. Related references: PMID:9770471
• Localizes to the mitochondrial matrix and mitochondrial nucleoid, where mtDNA replication and maintenance occur.
• Associated with a spectrum of mitochondrial disorders, including progressive external ophthalmoplegia, Leigh syndrome, and Alpers syndrome, highlighting its critical role in mtDNA stability.