Anti-DLG3 Rabbit Polyclonal Antibody for WB - Q92796

Core Product Specifications and Parameters

Biological Background: DLG3 Function and Localization

• DLG3 encodes the disks large homolog 3 protein, also known as synapse-associated protein 102 (SAP102), neuroendocrine-DLG, and XLMR.
• DLG3 is required for learning, most likely through its role in synaptic plasticity following NMDA receptor signaling.
• The protein is subject to post-translational modifications, including phosphorylation and acetylation, which may regulate its function.
• DLG3 contains SH3 domains and repeat regions; its 3D structure has been determined.
• Mutations in DLG3 are associated with X-linked intellectual disability (XLMR).
• The gene undergoes alternative splicing, producing multiple protein isoforms.

Experimental Guidance and Technical Tips

• The antibody was raised against a recombinant fusion protein corresponding to amino acids 464–817 of human DLG3. For WB, the predicted molecular weight is approximately 90 kDa; consider using an appropriate gel percentage (e.g., 8–10% SDS-PAGE) and standard semi-dry or wet transfer conditions.
• Validated applications include WB and ELISA. For other applications such as IHC or IF, pilot optimization is recommended.
• Confirmed cross-reactivity with human, mouse, and rat; validate the antibody in your specific tissue/cell lysate system to ensure specificity.
• For ELISA, consider using the recombinant immunogen as a positive control to establish optimal coating concentrations and detection conditions.
• Storage and handling: shipped on ice bag; upon receipt, aliquot and store at -20°C or below to maintain stability.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—supporting every stage from concept to clinic. This DLG3 antibody is suitable for neuroscience and synaptic plasticity studies; CamelBio can supply validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and assist in rare-target raw-material sourcing to accelerate your IVD development.