Anti-DEFB121 Rabbit Polyclonal Antibody for IF-P, IHC-P, ELISA - Q5J5C9

Core Product Specifications and Parameters

Biological Background: Beta-defensin 121 Function and Localization

• Beta-defensin 121 (DEFB121, also known as beta-defensin 21 or DEFB-21) is a member of the beta-defensin family of antimicrobial peptides.
• It possesses antibacterial activity, contributing to innate immune defense at mucosal surfaces.
• The protein is predicted to contain a signal peptide and conserved cysteine residues forming disulfide bonds, characteristic of the defensin family.
• DEFB121 is abundantly and specifically expressed in the male reproductive tract, as evidenced by tissue-specific expression profiling.
• Following secretion, the protein likely acts in the extracellular milieu to protect the male reproductive epithelium.
• Its restricted expression pattern suggests a specialized role in reproductive tract immunity, potentially influencing sperm maturation and fertility.

Experimental Guidance and Technical Tips

• For immunofluorescence (IF-P) or immunohistochemistry (IHC-P), consider optimizing antigen retrieval and permeabilization steps, as the target is secreted.
• Given the polyclonal nature, lot-to-lot variability may occur; validate each new batch in your sample system.
• In ELISA applications, the antibody can be used for detection of recombinant or native DEFB121; cross-reactivity with mouse and rat orthologs should be confirmed in your assay conditions.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research teams with reliable access to IVD raw materials, including validated antibodies, antigens, and ancillary reagents. For researchers studying reproductive immunology or antimicrobial peptides, we offer DEFB121 Rabbit Polyclonal Antibody as a tool for IF-P, IHC-P, and ELISA. Our one-stop sourcing model supports your project from target identification to assay development, ensuring consistent supply and technical guidance.