Anti-DCR2 Monoclonal Antibody for WB, IHC-P, ELISA - Q9UBN6

Core Product Specifications and Parameters

Biological Background: DCR2 Function and Localization

• DCR2, also known as tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), decoy receptor 2, TRAIL-R4, TRUNDD, and CD264, is a member of the TNF receptor superfamily. It acts as a receptor for the cytotoxic ligand TRAIL. Related references: PMID:9430226
• The receptor contains a truncated death domain, rendering it incapable of inducing apoptosis; instead, it protects cells against TRAIL-mediated apoptosis. Related references: PMID:9537512
• Reports are contradictory regarding its ability to activate the NF-kappa-B pathway; some studies suggest it cannot, while others indicate it can. Related references: PMID:9382840, PMID:9430226
• DCR2 is a membrane-bound protein with a signal peptide, transmembrane helix, and extracellular domains containing cysteine-rich repeats characteristic of the TNF receptor family.
• It is widely expressed, with notable expression in fetal kidney, lung, and liver, as well as adult testis, liver, and various other tissues including peripheral blood leukocytes and ovary.
• The protein undergoes post-translational modifications such as disulfide bond formation and glycosylation, as indicated by UniProt keywords.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 287–386 of human DCR2 (UniProt Q9UBN6), which lies within the intracellular domain. This region is expected to be accessible for detection in whole-cell lysates and paraffin-embedded tissues.
• For Western blotting (WB), the theoretical molecular weight is approximately 42 kDa; however, post-translational modifications may cause shifts. Validate detection in your specific sample system.
• For immunohistochemistry (IHC-P), antigen retrieval conditions may need optimization for each tissue type.
• ELISA applications may utilize this antibody as a capture or detection reagent; pairing with other clones or antibodies against different epitopes should be validated experimentally.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio specializes in providing diagnostic manufacturers, laboratories, and research institutes with comprehensive access to IVD raw materials, technical services, and consulting support. From this anti-DCR2 rabbit monoclonal antibody to validated antibody pairs, optimized bulk ancillary reagents, and rare target sourcing, we bridge your workflow from concept to clinic. Our expertise in apoptosis and TNF receptor superfamily targets ensures that you receive tailored sourcing solutions for your TRAIL-related research and assay development.