Anti-DCDC2 Rabbit Polyclonal Antibody for WB and ELISA - Q9UHG0

Core Product Specifications and Parameters

Biological Background: DCDC2 Function and Localization

• DCDC2 is a member of the doublecortin domain-containing protein family and includes a doublecortin domain, playing roles in cellular processes.
• It inhibits canonical Wnt signaling pathway (PubMed:25557784).
  Related references:
  PMID:25557784
• Involved in neuronal migration during development of the cerebral neocortex (By similarity).
• Participates in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779).
  Related references:
  PMID:25601850 PMID:27319779
• Subcellularly localizes to cilia, including the axoneme and kinocilium, as well as the cytoplasm and cytoskeleton.
• Ubiquitously expressed with high expression in brain regions such as the entorhinal cortex, inferior temporal cortex, medial temporal cortex, hypothalamus, amygdala, and hippocampus (PubMed:10601354, PubMed:16278297). At the protein level, also expressed in liver cholangiocytes (PubMed:27319779).
  Related references:
  PMID:10601354 PMID:16278297 PMID:27319779
• Associated with keywords including ciliopathy, deafness, nephronophthisis, alternative splicing, and phosphoprotein, indicating roles in disease and post-translational modification.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (aa 1-250) of human DCDC2; thus, consider its reactivity with splice variants or truncated forms.
• For Western blot, the predicted molecular weight is ~53 kDa; validate with positive controls such as brain or liver lysates that express DCDC2.
• For ELISA, using the recombinant protein immunogen as a standard can help establish assay conditions.
• Due to cross-reactivity with mouse and rat, this antibody may be suitable for comparative studies across these species; verify in the relevant model system.

CamelBio: Your One-Stop Sourcing Bridge

As a B2B IVD raw material partner, CamelBio provides one-stop access to validated antibody pairs, optimized polyclonal and monoclonal antibodies, bulk ancillary reagents, and rare target sourcing. For DCDC2-related research in Wnt signaling, neuronal migration, and ciliopathies, our platform streamlines procurement from concept to clinic, supporting diagnostic development with reliable reagents.