Anti-DCAF17 Rabbit Polyclonal Antibody for WB, ELISA - Q5H9S7

Core Product Specifications and Parameters

Biological Background: DCAF17 Function and Localization

• DCAF17 (DDB1- and CUL4-associated factor 17), also known as C2orf37 or C20orf37, is encoded by the DCAF17 gene; alternative splicing produces multiple isoforms.
• It functions as a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex, facilitating ubiquitination of target proteins.
• The protein contains a transmembrane helix and localizes to the membrane, nucleus, and nucleolus.
• Ubiquitously expressed in human tissues.
• Keywords and associated diseases include deafness, diabetes mellitus, hypotrichosis, and intellectual disability, implicating DCAF17 in these conditions.
• Part of the Ubl conjugation pathway, linking it to ubiquitin-like protein modifications.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 235–335 of human DCAF17; when designing validation experiments, consider this central region.
• The antibody is suitable for Western blot (WB) and ELISA; a band at approximately 59 kDa is expected for WB, consistent with the predicted molecular weight.
• The antibody cross-reacts with rat; validate in the relevant sample system to confirm reactivity.
• For ELISA, optimize coating antigen concentration and detection conditions for best performance.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a one-stop IVD raw-material sourcing partner, providing diagnostic manufacturers and research institutes with validated antibodies, bulk ancillary reagents, and rare target raw materials. For DCAF17 research—especially in ubiquitination pathways and associated disease studies—we offer polyclonal and monoclonal antibody options, antigen-grade proteins, and customized sourcing solutions to streamline your development from concept to clinic.