Anti-Cytokeratin 13 (KRT13) Rabbit Polyclonal Antibody for WB, IHC-P, IF-P, ELISA - P13646

Core Product Specifications and Parameters

Biological Background: Cytokeratin 13 (KRT13) Function and Localization

• Cytokeratin 13 (KRT13) is a type I keratin intermediate filament protein encoded by the KRT13 gene.
• It forms heterodimers with the type II keratin KRT4, assembling into keratin intermediate filament networks that provide structural integrity and mechanical stability to mucosal stratified squamous epithelia (PubMed:7493031). Related references: PMID:7493031
• KRT13 is essential for postnatal tongue mucosal cell homeostasis and tissue organization in response to mechanical stress, potentially through regulation of the G1/S phase cyclins CCNE1 and CCNE2.
• Subcellularly, KRT13 localizes to the cytoplasmic intermediate filament network.
• Post‑translational modifications include phosphorylation, methylation, and glycosylation, which may regulate filament dynamics and function.
• Tissue expression is prominent in exocervix, esophagus, and placenta, with detectable levels also in epidermal sweat gland ducts.
• Mutations in KRT13 are associated with white sponge nevus (WSN2), a benign mucosal disorder.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 269–458 of human KRT13, an internal region; the antibody is therefore likely to recognize both full‑length and potential isoform(s).
• Validated applications include Western blotting, immunofluorescence (IF‑P), immunohistochemistry (IHC‑P), and ELISA. Optimize dilution and detection conditions for each assay.
• For tissue‑based applications, include mucosa‑derived samples (e.g., tongue, esophageal, or cervical epithelium) as positive controls, and consider using a blocking strategy that minimizes non‑specific binding in keratin‑rich tissues.
• As a polyclonal antibody, lot‑to‑lot consistency should be verified; using a validated reference standard is recommended.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your integrated partner for IVD raw‑material procurement, offering this anti‑Cytokeratin 13 rabbit polyclonal antibody alongside a comprehensive portfolio of diagnostic‑grade reagents. We support mucosal biology and epithelial research programs with validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. For custom or rare‑target sourcing needs, our global supply network ensures reliable, one‑stop access from concept to clinic.