Anti-CTRL/CTRL1 Rabbit Monoclonal Antibody - P40313

Core Product Specifications and Parameters

Biological Background: CTRL Function and Localization

• The CTRL (CTRL1) gene encodes chymotrypsin-like protease CTRL-1, a member of the serine protease family with hydrolase activity.
• It is synthesized as a zymogen with an N-terminal signal peptide, suggesting secretion and extracellular function.
• The mature protein contains conserved disulfide bonds and glycosylation sites, contributing to structural stability and folding.
• UniProt classifies CTRL-1 under reference proteome and highlights its identification in proteomics datasets (Keywords: Proteomics identification).
• Its calculated molecular weight is approximately 28 kDa (UniProt: 28002 Da), consistent with the 28 kDa observed by western blot.
• Additional keywords include signal peptide and zymogen, reflecting its inactive precursor form that requires proteolytic processing for activation.

Experimental Guidance and Technical Tips

• For western blotting, expect a predominant band near 28 kDa in relevant tissue or cell lysates; validate expression in target systems.
• The immunogen targets a peptide within residues 165–264; the antibody may perform well in denaturing applications. Confirm performance in native conditions such as IHC-P or IF-P.
• Cross-reactivity with mouse and rat supports use in rodent models; verify species-specific reactivity in pilot experiments.
• As a secreted protease, consider appropriate permeabilization steps for intracellular detection via immunofluorescence or immunohistochemistry.
• Handle samples with protease inhibitors and on ice to prevent potential autolysis or degradation during preparation.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive supply partner for IVD raw materials, offering this high-quality anti-CTRL monoclonal antibody to diagnostic developers and researchers. Beyond single antibodies, we can source validated antibody pairs, bulk reagents, and ancillary proteins for serine protease research. Whether you require rare target reagents or large-volume production, CamelBio streamlines procurement from discovery to final assay development.