Anti-CTBP2 Rabbit Monoclonal Antibody for WB, IHC-P, IF/ICC, IP, ELISA - P56545

Core Product Specifications and Parameters

Biological Background: CTBP2 Function and Localization

• CTBP2 encodes C-terminal-binding protein 2, an evolutionarily conserved transcriptional corepressor and NAD-dependent oxidoreductase.
• Functions as a corepressor targeting diverse transcription regulators; also implicated in brown adipose tissue (BAT) differentiation (by similarity).
• Isoform 2 likely acts as a scaffold for specialized synapses, highlighting a structural role at neuronal contacts.
• Expressed ubiquitously, with highest levels detected in heart, skeletal muscle, and pancreas.
• Localizes predominantly to the nucleus, with isoform-specific presence at synapses.
• Post-translational modifications include phosphorylation and methylation, modulating protein interactions and stability.
• Keywords: Alternative splicing, host-virus interaction, methylated, phosphoprotein, reference proteome, repressor.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide spanning amino acids 346-445 of human CTBP2; the antibody detects an expected band around 49 kDa in Western blot.
• For immunohistochemistry (IHC-P) and immunofluorescence (IF/ICC), consider validating in human, mouse, and rat tissue specimens, as cross-reactivity is reported.
• Applications such as immunoprecipitation (IP) and ELISA are supported; optimize antibody dilution and incubation conditions in your experimental system.
• Always include appropriate positive and negative controls, and consider pre-adsorption tests to confirm specificity in your sample type.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and research laboratories with a comprehensive portfolio of IVD raw materials, including validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. This anti-CTBP2 monoclonal antibody serves transcriptional regulation and synapse biology research, and we can further assist in sourcing rare-target raw materials to accelerate your assay development from concept to clinic.