Anti-CSRP2 Polyclonal Antibody for WB, ELISA - Q16527

Core Product Specifications and Parameters

Biological Background: CSRP2 Function and Localization

• CSRP2, also known as Cysteine and glycine-rich protein 2 (CRP2), LIM domain only protein 5 (LMO-5), and Smooth muscle cell LIM protein (SmLIM), is a member of the CSRP family.
• It functions as a developmental protein involved in smooth muscle cell differentiation; its expression is drastically down-regulated by PDGF-BB or cell injury, promoting smooth muscle cell proliferation and dedifferentiation.
• CSRP2 appears to play a role in the development of the embryonic vascular system.
• The protein localizes to the nucleus.
• It is highly expressed in the aorta, with little to no expression in heart and skeletal muscle.
• CSRP2 contains LIM domains that bind zinc and is subject to post-translational modifications including acetylation, isopeptide bond formation, and ubiquitin-like conjugation.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the full-length human CSRP2 protein (amino acids 1-193). For Western blot, consider using whole cell lysates from vascular smooth muscle cells or aortic tissue, and validate the antibody's specificity using appropriate controls.
• For ELISA, test the antibody against recombinant CSRP2 or native protein in cell/tissue extracts; optimize coating and detection conditions.
• Given the cross-reactivity with mouse, this antibody may be suitable for studies in mouse models of vascular biology and smooth muscle pathology; confirm compatibility with your experimental system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio streamlines IVD raw-material procurement, providing validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents for diagnostic and research applications. This CSRP2 antibody supports studies in vascular development and smooth muscle biology, and CamelBio can assist in sourcing additional reagents for your workflow. As a one-stop partner, we help bridge your concept to clinic with consistent supply chain solutions.