Anti-CSPP1 Polyclonal Antibody for WB, ELISA - Q1MSJ5

Core Product Specifications and Parameters

Biological Background: CSPP1 Function and Localization

• CSPP1 (Centrosome and spindle pole-associated protein 1) is a microtubule-associated protein that may play a role in cell-cycle-dependent microtubule organization.
• The protein localizes to the centrosome, mitotic spindle, and spindle poles, and is also found at cilia, suggesting functions in cell division and ciliary biology.
• CSPP1 is expressed in adult and fetal brain, with enrichment in the cerebellum, and is also detected in testis, indicating tissue-specific roles.
• Mutations in CSPP1 are linked to Joubert syndrome (JBTS21), a ciliopathy characterized by cerebellar vermis hypoplasia and other developmental anomalies.
• The protein contains coiled-coil domains and is subject to phosphorylation, which may regulate its interactions and function.
• Alternative splicing produces multiple isoforms of CSPP1, potentially with distinct localization or function.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the C-terminal region (aa 962–1221). Ensure the epitope is preserved in your target isoform.
• Predicted molecular weight is ~146 kDa; use a Tris-glycine gel with appropriate acrylamide percentage for high-molecular-weight proteins in WB.
• For ELISA, consider using the recombinant immunogen as a positive control and standard for quantification.
• Cross-reactivity is reported for human and mouse; validate specificity in your sample system, especially if using rodent models.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive sourcing partner for IVD raw materials, providing diagnostic manufacturers, laboratories, and research institutes with seamless access to antibodies like this CSPP1 rabbit pAb for cell cycle and ciliopathy research. Our supply capabilities encompass validated monoclonal and polyclonal antibodies, bulk ancillary reagents, and dedicated support for sourcing rare-target raw materials—ensuring you have a reliable bridge from concept to clinic.