Anti-CSNK1G2 Rabbit Polyclonal Antibody for WB, ELISA - P78368

Core Product Specifications and Parameters

Biological Background: Casein Kinase I Isoform Gamma-2 Function and Localization

• Encoded by the CSNK1G2 gene, casein kinase I isoform gamma-2 (CK1γ2) is a serine/threonine-protein kinase that belongs to the casein kinase 1 family, preferentially phosphorylating acidic substrates such as caseins.
• Acts as a key regulator in the Wnt signaling pathway, modulating β-catenin-dependent transcription and participating in embryonic development and cell fate determination (by similarity).
• Phosphorylates multiple downstream targets, including COL4A3BP/CERT (regulating ceramide trafficking), MTA1, and SMAD3, thereby influencing ER-to-Golgi transport and TGF-beta signaling.
  Related references:
  PMID:15077195 PMID:15917222 PMID:18794808
• Triggers PER1 proteasomal degradation via phosphorylation, linking CK1γ2 to circadian rhythm control.
  Related references:
  PMID:15077195 PMID:15917222 PMID:18794808
• Involved in the regulation of reactive oxygen species (ROS) levels, suggesting a role in oxidative stress responses.
  Related references:
  PMID:37099597
• Localizes predominantly to the cytoplasm and cell cortex, consistent with its functions in membrane trafficking and signal transduction.
• Highly expressed in testis, with documented roles in brain development and neurotransmitter release from synaptic vesicles (by similarity).
• Classified as a phosphoprotein and ATP-binding kinase, subject to regulatory phosphorylation events that modulate its activity.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 316–415 in the C-terminal region of human CSNK1G2; consider using this information when designing peptide-blocking or competition assays.
• For Western blot, a band around 47 kDa is expected; verify molecular weight markers and optimize loading amounts for your specific sample type.
• Cross-reactivity with mouse and rat CSNK1G2 has been confirmed; validate in the relevant sample system if using non-human tissues.
• This antibody is suitable for ELISA; for quantitative applications, consider pairing with a capture antibody if developing a sandwich immunoassay.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a dedicated one-stop sourcing partner for IVD raw materials, connecting diagnostic manufacturers and researchers with high-quality antibodies like this CSNK1G2 polyclonal. Leveraging a comprehensive supply network, we offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and specialized procurement for rare-target raw materials. Whether you are developing kinase activity assays or studying Wnt signaling pathways, CamelBio streamlines your supply chain from concept to clinic.