Anti-CRYGS Polyclonal Antibody for WB, ELISA - P22914

Core Product Specifications and Parameters

Biological Background: CRYGS Function and Localization

• CRYGS encodes gamma-crystallin S, also known as beta-crystallin S or gamma-S-crystallin, a key structural protein of the vertebrate eye lens.
• Crystallins, including gamma-crystallin S, are the dominant structural components of the lens, essential for maintaining transparency and refractive properties.
• The protein belongs to the beta/gamma-crystallin superfamily, characterized by Greek key motif repeats, as indicated by the "Repeat" keyword.
• Mutations in CRYGS are linked to cataract formation, underlining its clinical significance in lens-related diseases.
• Post-translational modifications such as acetylation have been identified in gamma-crystallin S.
• The molecular weight of the native protein is approximately 21 kDa.

Experimental Guidance and Technical Tips

• For Western blotting, denaturing and reducing conditions are typically suitable; optimize protein loading and antibody dilution for your specific samples.
• Validate the antibody's reactivity in relevant tissue lysates (e.g., lens) or cell lines expressing CRYGS, and include appropriate controls.
• In ELISA, the antibody can be used for direct or indirect detection; ensure proper antigen coating and blocking steps.
• Consider the predicted molecular weight (~21 kDa) when interpreting WB bands; post-translational modifications may cause slight shifts.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a strategic one-stop sourcing bridge for IVD manufacturers, research laboratories, and diagnostic developers, offering a comprehensive portfolio including validated antibody pairs, monoclonal and polyclonal antibodies, and ancillary reagents. For projects involving lens biology, cataract research, or crystallin targets, we facilitate access to hard-to-find raw materials and provide tailored supply solutions. Our mission is to streamline your procurement from concept to clinic with reliability and expertise.