Anti-CRMP5/DPYSL5 Rabbit Monoclonal Antibody for WB, IHC-P, ELISA - Q9BPU6

Core Product Specifications and Parameters

Biological Background: Dihydropyrimidinase-related protein 5 Function and Localization

• Dihydropyrimidinase-related protein 5 (DPYSL5), also known as CRMP5, CRAM, or ULIP-6, is a member of the collapsin response mediator protein family implicated in neuronal development.
• DPYSL5 functions as a negative regulator of dendrite outgrowth, contributing to the control of neuronal morphology and connectivity.
• The protein localizes predominantly to the cytoplasm, where it participates in intracellular signaling pathways.
• DPYSL5 is subject to post-translational modifications, including phosphorylation and methylation, which may modulate its activity and interactions.
• Genetic variations in DPYSL5 have been associated with disease phenotypes, marking it as a protein with clinical relevance.
• The protein has a calculated molecular weight of approximately 61 kDa and has been characterized by direct protein sequencing and proteomics approaches.

Experimental Guidance and Technical Tips

• The immunogen used is a synthetic peptide from amino acids 465-564, which may confer high specificity to this monoclonal antibody; consider using it for applications requiring defined epitope recognition.
• For Western blotting, expect detection of a band near 61 kDa; validate in lysates from human, mouse, or rat samples depending on your experimental system.
• In immunohistochemistry (IHC-P), optimize antigen retrieval and antibody dilution for your tissue type, as staining patterns may reflect cytoplasmic localization.
• When performing ELISA, include appropriate controls and consider testing different coating concentrations to maximize signal-to-noise ratio.
• As with any antibody, perform pilot experiments to establish optimal working conditions for your specific assay.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with streamlined access to high-quality IVD raw materials, including validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents. For neuroscience and dendrite outgrowth research, this anti-CRMP5/DPYSL5 monoclonal antibody exemplifies our commitment to supplying reliable tools for your development pipeline. Let CamelBio be your partner in sourcing rare-target reagents and supporting your journey from concept to clinic.