Anti-COPS6 Rabbit Polyclonal Antibody for WB, IF/ICC, ELISA - Q7L5N1

Core Product Specifications and Parameters

Biological Background: COPS6 Function and Localization

• COPS6 (also known as CSN6, MOV34-34KD, or hVIP) is the COP9 signalosome complex subunit 6, a conserved component of the COP9 signalosome (CSN).
• The CSN complex regulates the ubiquitin-proteasome system by mediating deneddylation of cullin subunits in SCF-type E3 ubiquitin ligases, thereby modulating their activity. Related references: PMID:29191936, PMID:16824163, PMID:20534510, PMID:20400937, PMID:22193163, PMID:25124036
• COPS6/CSN is involved in phosphorylation of key signaling molecules including TP53/p53, JUN/c-Jun, and NFKBIA/IκBα, potentially via associated kinases CK2 and PKD, influencing their stability and degradation. Related references: PMID:15981862, PMID:17449641
• It exhibits glucocorticoid receptor-responsive activity, indicating a role in hormone signaling pathways. Related references: PMID:23852393
• COPS6 stabilizes the E3 ubiquitin ligase COP1 by reducing its auto-ubiquitination and turnover, thereby impacting the ubiquitination of COP1 targets. Related references: PMID:25402001
• Subcellularly, COPS6 localizes to both the nucleus and cytoplasm, with enrichment in the perinuclear region.
• It is widely expressed across tissues, consistent with its fundamental regulatory roles.
• Keywords associated with COPS6 include signalosome, host-virus interaction, and reference proteome, reflecting its involvement in diverse biological processes.

Experimental Guidance and Technical Tips

• For Western blotting, the predicted molecular weight is approximately 36 kDa; validate in your sample system to confirm specific band detection.
• For IF/ICC, consider appropriate fixation and permeabilization protocols to detect both nuclear and cytoplasmic COPS6 pools.
• For ELISA, titrate the antibody and optimize coating and detection conditions empirically using the relevant target antigen.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and researchers with a comprehensive portfolio of IVD raw materials, including validated antibodies, antigens, and ancillary reagents. This anti-COPS6 antibody supports research into ubiquitin-mediated proteolysis, signalosome function, and related disease pathways. For bulk orders, custom formulations, or rare target sourcing, CamelBio offers tailored procurement solutions to streamline your development pipeline.