Anti-Contactin 2 Rabbit Polyclonal Antibody for WB, ELISA - Q02246

Core Product Specifications and Parameters

Biological Background: Contactin 2 Function and Localization

• Contactin-2, also known as TAG-1, axonin-1, or TAX-1, is a neural cell adhesion molecule belonging to the immunoglobulin superfamily.
• It plays a critical role in the organization of axonal domains at nodes of Ranvier by clustering voltage-gated potassium channels at the juxtaparanodal region, acting in conjunction with CNTNAP2.
• Contactin-2 may also mediate cell adhesion interactions, contributing to neuronal network formation and maintenance.
• The protein is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor.
• Its structure includes immunoglobulin-like domains and disulfide bonds, characteristic of adhesion molecules, and it is glycosylated.
• Subcellularly, Contactin-2 localizes primarily to the cell membrane, consistent with its role in cell surface interactions.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a C-terminal fragment (aa 785-1012) of human Contactin 2. This region may encompass part of the fibronectin type III domains or membrane-proximal sequences; consider this when designing epitope-related experiments.
• For Western blot, the predicted molecular weight is ~113 kDa, but glycosylation may cause a shift in the observed band. Validate the antibody in your relevant sample system under optimized conditions.
• It is suitable for ELISA; ensure proper coating and detection conditions are established in your assay.
• Cross-reactivity is reported for mouse and rat; verify performance in these species if your study involves them.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your dedicated partner for one-stop IVD raw material sourcing, offering this high-quality anti-Contactin 2 polyclonal antibody to support neuroscience and axonal biology research. We provide a comprehensive portfolio of validated antibodies, bulk ancillary reagents, and custom sourcing solutions for rare targets, empowering diagnostic manufacturers and researchers from concept to clinic. Trust CamelBio to streamline your supply chain with reliable materials and expert support.