Anti-COLEC11 Rabbit Polyclonal Antibody for WB, IHC-P, ELISA - Q9BWP8

Core Product Specifications and Parameters

Biological Background: Collectin-11 Function and Localization

• Collectin-11 (COLEC11), also known as collectin kidney protein 1 (CL-K1), is a calcium-dependent lectin belonging to the collectin family of innate immune proteins.
• It plays a critical role in innate immunity by binding non-self sugars on microorganisms and activating the complement cascade via recruitment of MASP-1. Related references: PMID:20956340, PMID:25912189
• COLEC11 also recognizes fucosylated glycans and lipopolysaccharides, contributing to pathogen recognition. Related references: PMID:17179669, PMID:25912189
• It is involved in apoptosis by binding DNA on apoptotic cells in a calcium-independent manner, triggering complement activation.
• During embryogenesis, COLEC11 serves as a guidance cue for neural crest cell migration and other developmental processes. Related references: PMID:21258343, PMID:28301481
• The protein is secreted and shows ubiquitous expression, with confirmed protein presence in adrenal gland, kidney, liver, ovaries, and testis. Related references: PMID:17179669, PMID:20956340
• COLEC11 contains a collagen-like domain, a coiled-coil region, and a carbohydrate-recognition domain, with disulfide bonds stabilizing its structure.
• Alternative splicing produces multiple isoforms, including CL-K1-I, CL-K1-II, and others.

Experimental Guidance and Technical Tips

• The immunogen spans the N-terminal region (aa 26-271), which includes the collagen-like domain and part of the coiled-coil region; consider this when designing detection strategies.
• For WB, the expected band is approximately 29 kDa, but glycosylation or dimerization might result in additional bands; validate in your sample system.
• For IHC-P, validate in human tissue sections known to express COLEC11, such as kidney or adrenal gland.
• For ELISA, pair with a suitable detection antibody recognizing a distinct epitope.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with comprehensive access to IVD raw materials, including validated antibody pairs, optimized polyclonal antibodies, and bulk ancillary reagents. For COLEC11-related projects in immunology or developmental biology, our one-stop service streamlines procurement from concept to clinic, helping you source rare targets and scale your assays efficiently.