Anti-Coilin Polyclonal Antibody for WB, IP, ELISA - P38432

Core Product Specifications and Parameters

Biological Background: Coilin Function and Localization

• Coilin, also known as p80-coilin, is a protein encoded by the COIL (CLN80) gene in humans. It is a major component of Cajal bodies (coiled bodies), specialized nuclear domains involved in the modification and assembly of small nuclear ribonucleoproteins (snRNPs).
• Coilin localizes predominantly to the nucleus and is specifically enriched in Cajal bodies, where it serves as a structural scaffold and regulatory hub for snRNP biogenesis and trafficking.
• Post-translational modifications of coilin include phosphorylation, isopeptide bond formation, and ubiquitin-like (Ubl) conjugation, which may modulate its function and Cajal body integrity.
• Coilin is ubiquitously expressed across all examined cell types, reflecting its essential role in fundamental RNA processing pathways.

Experimental Guidance and Technical Tips

• The immunogen used to generate this antibody corresponds to amino acids 297-576 of human coilin, a region likely spanning functional domains; consider this when interpreting epitope recognition.
• For Western blotting, a band at approximately 63 kDa is expected; validate specificity in the relevant cell or tissue lysates.
• This antibody is qualified for immunoprecipitation (IP) and ELISA; users should optimize conditions for their specific experimental systems.
• Cross-reactivity with mouse and rat orthologs is reported; verify sequence homology to predict reactivity in other species.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a dedicated one-stop partner for IVD raw-material sourcing, supporting diagnostic manufacturers and researchers from concept to clinic. This anti-coilin polyclonal antibody, targeting a key Cajal body marker, complements our portfolio of validated antibody pairs, monoclonal/polyclonal options, and bulk ancillary reagents for RNA processing and nuclear architecture studies. Whether you require routine supply or rare-target raw material procurement, CamelBio provides reliable access and technical consulting to accelerate your assay development.