Anti-CNNM4/ACDP4 Polyclonal Antibody for WB, ELISA - Q6P4Q7

Core Product Specifications and Parameters

Biological Background: CNNM4 Function and Localization

• CNNM4 (also known as ACDP4 or Cyclin-M4) is a metal transporter belonging to the ancient conserved domain-containing protein family.
• It interacts with the metal ion chaperone COX11, suggesting a role in sensory neuron functions (By similarity).
• CNNM4 may be involved in biomineralization processes and retinal function, as indicated by associated disease variants.
• The protein is localized at the cell membrane and contains CBS domains and transmembrane regions.
• Alternative splicing generates multiple isoforms; post-translational modifications include glycosylation and phosphorylation.
• Mutations in CNNM4 are linked to amelogenesis imperfecta and cone-rod dystrophy, highlighting its importance in hard tissue formation and vision.
• CNNM4 is widely expressed, with highest levels in the heart, and is associated with ion transport and transmembrane transport processes.

Experimental Guidance and Technical Tips

• This antibody was raised against a synthetic peptide spanning amino acids 700–775 of human CNNM4, located in the C-terminal region. Consider whether this region is conserved across isoforms and species for your experiments.
• For Western blot (WB), the predicted molecular weight is approximately 87 kDa. Include appropriate positive and negative controls, and verify band specificity using knockout or knockdown samples if available.
• For ELISA, titrate the antibody and optimize blocking conditions to reduce non-specific binding. Cross-reactivity has been reported with mouse and rat CNNM4, but validate for your specific sample type.
• When using in immunofluorescence or other applications not listed, pilot testing is recommended to determine suitability.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio streamlines the procurement of high-quality IVD raw materials, offering validated polyclonal antibodies like this anti-CNNM4 antibody, along with matched antibody pairs, recombinant proteins, and bulk ancillary reagents. Whether you need additional isoforms, monoclonal alternatives, or rare-target reagents for metal transporter studies or retinal disease research, CamelBio’s technical team provides tailored sourcing support from discovery to clinical application.