Anti-CNMD Polyclonal Antibody for WB, ELISA - O75829

Core Product Specifications and Parameters

Biological Background: CNMD Function and Localization

• CNMD, also known as CHM1, LECT1, or Chondromodulin, is encoded by the CNMD gene and may exist in alternatively spliced isoforms.
• It functions as a bifunctional growth regulator that stimulates chondrocyte growth in the presence of FGF while inhibiting vascular endothelial cell proliferation and tube formation, thereby acting as an antiangiogenic factor in cardiac valves.
• The protein is secreted and localizes to the extracellular matrix and space, and is associated with the endomembrane system.
• It is highly expressed in cartilage and cardiac valves, with decreased expression observed in valvular heart disease; weakly detected in chondrosarcoma.
• Post-translational modifications include glycosylation, disulfide bond formation, and cleavage at basic residues.
• Gene keywords: Chondrogenesis, Developmental protein, Differentiation, Extracellular matrix, Glycoprotein, Secreted.

Experimental Guidance and Technical Tips

• The immunogen (aa 75-334) targets the central region of human CNMD, likely recognizing multiple isoforms. Consider validating detection of expected ~37 kDa band in WB using relevant cell or tissue lysates (e.g., chondrocytes, cartilage).
• For ELISA, a recombinant CNMD protein may serve as a positive control and standard.
• As a secreted and extracellular matrix protein, sample preparation may benefit from methods that enrich for secreted factors or ECM components.
• Cross-reactivity is reported for human; performance in other species should be experimentally verified.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic and research laboratories a one-stop solution for IVD raw materials, including antibodies against bone and cardiovascular targets like CNMD. With this anti-CNMD polyclonal antibody validated for WB and ELISA, customers can access optimized reagents alongside bulk ancillary supplies and sourcing for rare targets. From discovery to clinical applications, CamelBio bridges your raw-material needs with comprehensive support.