Anti-CNDP1 Polyclonal Antibody for WB, ELISA - Q96KN2

Core Product Specifications and Parameters

Biological Background: CNDP1 Function and Localization

• CNDP1, also known as beta-Ala-His dipeptidase, carnosine dipeptidase 1, glutamate carboxypeptidase-like protein 2, or serum carnosinase, is a secreted zinc metalloprotease.
• It catalyzes the hydrolysis of Xaa-His dipeptides, with highest activity toward carnosine (beta-alanyl-L-histidine), a dipeptide with antioxidant and pH-buffering roles.
• The enzyme is found in serum and the adult central nervous system; its absence in serum is associated with homocarnosinosis, a rare neurological disorder.
• CNDP1 is a glycoprotein and phosphoprotein, suggesting post-translational regulation, and it binds zinc as a metal cofactor essential for catalytic activity.
• The gene aliases include CN1 and CPGL2, and the protein is classified under the M20 metallopeptidase family.

Experimental Guidance and Technical Tips

• The immunogen comprises the N-terminal 280 amino acids of human CNDP1; this region may allow detection of both full-length and potential N-terminal fragments.
• For Western blot, consider validating detection of endogenous CNDP1 in serum or tissue lysates from human, mouse, or rat, given the reported cross-reactivity.
• In ELISA applications, this polyclonal antibody can be explored as a capture or detection reagent; pairing with a monoclonal antibody may improve specificity for quantitative assays.
• The predicted molecular weight is 57 kDa, but note that glycosylation may cause migration shifts; always include appropriate controls.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers and research institutes a streamlined path to high-quality IVD raw materials, including validated antibody pairs, optimized polyclonal antibodies, and bulk ancillary reagents. With this anti-CNDP1 antibody, researchers studying carnosine metabolism or serum carnosinase biomarkers can rely on CamelBio's comprehensive supply chain and sourcing expertise to secure consistent, performance-characterized reagents. Additionally, our platform supports customized procurement of rare-target antibodies and related biochemicals, helping you move efficiently from concept to clinic.