Anti-CLVS2 Rabbit Polyclonal Antibody for WB, ELISA - Q5SYC1

Core Product Specifications and Parameters

Biological Background: Clavesin-2 Function and Localization

• CLVS2 encodes Clavesin-2, also known as retinaldehyde-binding protein 1-like 2 (RLBP1L2) and clathrin vesicle-associated Sec14 protein 2.
• Clavesin-2 is required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity).
• It binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a phosphoinositide enriched in late endosomes/lysosomes.
• Subcellular localization includes the Golgi apparatus (trans-Golgi network membrane), cytoplasmic vesicles (clathrin-coated vesicles), and early endosome membrane.
• UniProt keywords indicate the protein undergoes alternative splicing, is a lipid-binding phosphoprotein, and has been identified in proteomics studies.
• The calculated molecular weight is approximately 38 kDa.

Experimental Guidance and Technical Tips

• For western blotting, the predicted molecular weight of human CLVS2 is 38 kDa; validate band specificity using appropriate positive and negative controls.
• Consider the immunogen design (amino acids 265–327) which may influence isoform detection—verify the target isoform in your experimental system.
• When performing ELISA, optimize coating antigen concentration and antibody dilution to achieve the desired sensitivity and dynamic range.
• Since CLVS2 is expressed in neurons and localizes to endosomal/lysosomal compartments, subcellular fractionation or enrichment may enhance detection in WB.
• Always confirm cross-reactivity and specificity in the relevant species and sample type before quantitative analysis.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with one-stop access to IVD raw materials, technical services, and consulting from concept to clinic. This anti-CLVS2 rabbit polyclonal antibody is part of our extensive portfolio supporting neuroscience and cell biology research. We offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing to streamline your assay development and supply chain.