Anti-CLN8 Polyclonal Antibody for WB, IHC-P, ELISA - Q9UBY8

Core Product Specifications and Parameters

Biological Background: CLN8 Function and Localization

• CLN8 is a transmembrane protein localized predominantly to the endoplasmic reticulum (ER) membrane, with additional presence in the ER-Golgi intermediate compartment membrane.
• It contains multiple transmembrane helices (UniProt keyword: Transmembrane helix), consistent with its integral membrane topology.
• Functional studies suggest that CLN8 may participate in cell proliferation during neuronal differentiation, potentially supporting normal brain development.
• The protein is implicated in protection against cell death, highlighting a role in cellular survival and stress response.
• Mutations in the CLN8 gene are associated with neuronal ceroid lipofuscinosis (NCL), a neurodegenerative disorder; disease-related keywords encompass epilepsy and intellectual disability.
• The predicted molecular weight is approximately 33 kDa (calculated from UniProt: 32787 Da), matching the observed protein weight.

Experimental Guidance and Technical Tips

• The antibody was raised against a synthetic peptide spanning amino acids 200–286 of human CLN8, targeting a C-terminal region. Peptide blocking experiments can be considered to validate binding specificity.
• In western blotting, a major band around 33 kDa is anticipated. Optimize antibody dilution and blocking conditions using a suitable positive control.
• For IHC-P, antigen retrieval protocols (e.g., heat-induced epitope retrieval) may improve detection; validate in the relevant tissue system.
• Cross-reactivity has been confirmed for human; reactivity with other species has not been tested and should be experimentally determined.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio simplifies your IVD raw‑material procurement by offering the CLN8 polyclonal antibody alongside a broad portfolio of validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare‑target sourcing. Whether you are developing neurodegenerative disease assays or ER‑focused research tools, our one‑stop supply chain and expert consulting support your journey from concept to clinic.