Anti-CLEC3B/Tetranectin Polyclonal Antibody for IF/ICC, ELISA - P05452

Core Product Specifications and Parameters

Biological Background: CLEC3B/Tetranectin Function and Localization

• Tetranectin is a secreted glycoprotein and a member of the C-type lectin domain family 3, also designated plasminogen kringle 4-binding protein.
• It specifically binds to plasminogen and to isolated kringle 4 domains, potentially modulating plasminogen activation.
• May participate in the sorting and packaging of molecules destined for exocytosis.
• Plays a role in retinal function (PubMed:35331648). Related references: PMID:35331648
• Found primarily in plasma; contains disulfide bonds and is glycosylated.
• Disease-associated variants have been documented (UniProt keyword).

Experimental Guidance and Technical Tips

• The immunogen spans the majority of the mature secreted protein (amino acids 22–202), likely enabling recognition of native tetranectin; consider validating reactivity in relevant biological samples such as plasma or cell supernatants.
• For IF/ICC, since tetranectin is secreted, effective permeabilization may be required to detect intracellular pools; optimize fixation and permeabilization conditions for your cell type.
• In ELISA, ensure proper blocking and washing steps to reduce background; the polyclonal nature may increase sensitivity but can also amplify cross-reactivity—include appropriate controls (e.g., antigen competition or knockout validation).
• Pairing with a capture antibody for sandwich ELISA may require empirical screening of compatible clones.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and researchers with comprehensive access to IVD raw materials, including validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. For tetranectin research and assay development, CamelBio can source antibodies and support rare target raw-material procurement. Our one-stop bridge covers every stage from concept to clinic, accelerating your assay development with integrated technical services.