Anti-CLEC3B/Tetranectin Monoclonal Antibody for WB, IF/ICC, ELISA - P05452

Core Product Specifications and Parameters

Biological Background: Tetranectin Function and Localization

• Tetranectin (CLEC3B) is a secreted glycoprotein of the C-type lectin family, also designated TN, TNA, and MCDR4.
• It binds plasminogen and isolated kringle 4, and may participate in the packaging of molecules destined for exocytosis.
• Tetranectin plays a role in retinal function (PubMed:35331648). Related references: PMID:35331648
• The protein is primarily found in plasma.
• Its structure features disulfide bonds and N-linked glycosylation, characteristic of extracellular lectins.
• Disease-associated variants in CLEC3B have been reported, linking it to various pathologies.

Experimental Guidance and Technical Tips

• The antibody was raised against a peptide spanning amino acids 103–202; consider this region when assessing epitope accessibility in native versus denaturing conditions.
• For western blot (WB), a band may be observed near 21–23 kDa (predicted full-length Tetranectin is ~23 kDa; post-translational cleavage may yield a 21 kDa product). Validate with appropriate controls.
• For immunofluorescence (IF/ICC), since Tetranectin is secreted, visualize with permeabilization to detect intracellular pools; Golgi-localized signals may be observed.
• This antibody is also validated for ELISA; titrate to optimize signal-to-noise ratio.
• Cross-reactivity with mouse and rat has been demonstrated; validate species-specific expression patterns in relevant tissue or cell lines.

CamelBio: Your One-Stop Sourcing Bridge

As a dedicated B2B provider, CamelBio offers a comprehensive range of IVD raw materials, including validated antibodies, bulk reagents, and technical consultation. This anti-Tetranectin monoclonal antibody supports research in retinal function, exocytosis, and plasma protein interactions. Inquire about custom sourcing, volume pricing, and additional ancillary reagents to accelerate your assay development.