Anti-CLEC1B Polyclonal Antibody for WB, ELISA - Q9P126

Core Product Specifications and Parameters

Biological Background: CLEC1B Function and Localization

• Serves as a platelet receptor for the lymphatic endothelial marker PDPN, initiating intracellular signaling. Related references: PMID:18215137
• Essential for blood/lymphatic vessel separation and thrombus formation, and acts as a negative regulator of lymphatic endothelial cell behavior. Related references: PMID:22556408
• Ligand binding triggers SRC/SYK/PLCG2 cascade, mediating platelet adhesion, aggregation, and secretion. Related references: PMID:18955485
• Plays a central role in cerebrovascular formation and integrity during embryonic development.
• Acts as a receptor for rhodocytin, a platelet-aggregating snake venom protein, leading to SYK-dependent signaling. Related references: PMID:16174766, PMID:18955485
• Serves as an attachment factor for HIV-1, facilitating its capture by platelets. Related references: PMID:16940507
• Expressed preferentially in the liver and on platelets; subcellularly localized to the membrane. The protein is a C-type lectin-like receptor with a signal-anchor, glycosylation, and alternative splicing.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the extracellular domain (amino acids 22-196), which may be suitable for detecting both full-length and soluble forms.
• For Western blot, consider using the predicted molecular weight of 27 kDa, but note that glycosylation may affect migration.
• Validate antibody performance in the relevant sample system, such as platelet lysates or liver tissue, given the tissue expression profile.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your one-stop IVD raw-material sourcing partner for immunodiagnostic development. This Anti-CLEC1B Polyclonal Antibody supports research into thrombosis, vascular biology, and infectious disease. Beyond this product, CamelBio offers validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing to streamline your assay development from concept to clinic.