Anti-CLEC11A Rabbit Polyclonal Antibody for WB, ELISA - Q9Y240

Core Product Specifications and Parameters

Biological Background: CLEC11A Function and Localization

• CLEC11A, also known as P47, SCGF, LSLCL, and CLECSF3, is a secreted and cytoplasmic growth factor belonging to the C-type lectin superfamily (UniProt: Q9Y240).
• It promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts, a process crucial for bone formation (PubMed:27976999). Related references: PMID:27976999
• CLEC11A is important for the repair and maintenance of adult bone, as evidenced by sequence similarities to related proteins (By similarity).
• Subcellularly, CLEC11A localizes to both the cytoplasm and is secreted into the extracellular space, consistent with its role as a growth factor.
• Tissue specificity analysis reveals high expression in skeletal tissues such as bone marrow, chondrocytes, and the perichondrium, with lower levels detected in lymphoid organs including spleen and thymus.
• Key post-translational features include glycosylation, disulfide bond formation, and a signal peptide, as indicated by UniProt keywords: Glycoprotein, Disulfide bond, Signal.
• It is classified as a growth factor and lectin, and has been identified through direct protein sequencing and proteomics.

Experimental Guidance and Technical Tips

• The immunogen spans nearly the full length (amino acids 22-323) of human CLEC11A, suggesting the polyclonal antibody may recognize multiple epitopes for robust detection.
• For Western blotting, consider that the predicted molecular weight is 36 kDa, but glycosylation may cause a shift; validate in your specific sample system.
• In ELISA applications, the antibody's polyclonal nature can enhance sensitivity; however, cross-reactivity with mouse is reported, so species-specific validation is recommended.
• For bone biology studies, consider employing mesenchymal progenitor cell differentiation models to confirm CLEC11A expression patterns.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and researchers with streamlined access to premium IVD raw materials, including this anti-CLEC11A polyclonal antibody for osteogenesis and skeletal biology research. Our comprehensive portfolio features validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents to accelerate your assay development. With expertise in sourcing rare and niche targets, CamelBio is your trusted partner from concept to clinic.