Anti-CHGB Rabbit Polyclonal Antibody for WB, ELISA - P05060

Core Product Specifications and Parameters

Biological Background: CHGB (Secretogranin-1) Function and Localization

• CHGB encodes secretogranin-1 (also known as chromogranin-B or secretogranin I), a member of the granin family of neuroendocrine secretory proteins.
• It is a neuroendocrine secretory granule protein that may serve as a precursor for biologically active peptides.
• Secretogranin-1 is localized to secretory granules and is secreted from neuroendocrine cells.
• It is expressed in the adrenal medulla and pheochromocytoma, and detected in cerebrospinal fluid and urine at the protein level, but not in liver. Related references: PMID:25326458 PMID:37453717
• Post-translational modifications include cleavage on pair of basic residues, disulfide bond formation, glycosylation, phosphorylation, sulfation, and proteoglycan attachment, as indicated by UniProt keywords.

Experimental Guidance and Technical Tips

• The immunogen, corresponding to amino acids 1-300 of human CHGB, targets the N-terminal region; consider this for detection antibody pairing in sandwich ELISA or Western blot.
• This antibody is reported for WB and ELISA; validate dilution factors and incubation conditions with relevant positive and negative controls.
• Cross-reactivity with human and mouse has been noted; verify performance in other species if required.
• As a secreted protein, CHGB may be present in cell supernatants or biological fluids; adapt sample preparation accordingly.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers and researchers a streamlined sourcing solution for IVD raw materials, including validated antibodies, bulk reagents, and rare target procurement. This CHGB antibody supports neuroendocrine secretory protein and biomarker research, from adrenal medulla to cerebrospinal fluid studies. Partner with us to accelerate your project from concept to clinic with reliable, one-stop raw material supply.