Anti-CETN1 Rabbit Polyclonal Antibody for WB, ELISA - Q12798

Core Product Specifications and Parameters

Biological Background: Centrin-1 Function and Localization

• Centrin-1 (also known as caltractin isoform 2) is a member of the centrin/calmodulin family of calcium-binding proteins.
• It plays a fundamental role in microtubule-organizing center structure and function, essential for centrosome integrity and cell cycle progression.
  Related references: PMID:8175926
• Centrin-1 is involved in sperm cilia formation, contributing to ciliary motility (By similarity).
• Subcellular localization includes the centrosome, cilium, and cytoskeleton, highlighting its role at the microtubule-organizing center.
• The protein contains EF-hand calcium-binding domains, enabling calcium-dependent regulation.
• CETN1 is implicated in cell division and mitosis, consistent with its centrosomal functions.

Experimental Guidance and Technical Tips

• This polyclonal antibody was raised against a recombinant protein corresponding to full-length human CETN1 (aa 1-172). It is suitable for detecting endogenous CETN1 in WB and ELISA.
• For Western blotting, a band around 20 kDa is expected. Consider optimizing loading controls and antibody concentrations for your specific sample type.
• The antibody has been shown to cross-react with mouse and rat centrin-1, making it useful for comparative studies across these species.
• For ELISA applications, the recombinant immunogen can serve as a positive control; however, user-side validation of assay conditions is recommended.

CamelBio: Your One-Stop Sourcing Bridge

As a dedicated supplier to the IVD industry, CamelBio streamlines access to critical raw materials. This anti-CETN1 antibody supports research in cell cycle, centrosome biology, and cilia function. Beyond this product, we offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, and ancillary reagents to accelerate assay development. For specialized needs, our team can source or develop rare-target reagents, helping diagnostic manufacturers and laboratories transition smoothly from concept to clinical application.