Anti-Ceruloplasmin Rabbit Polyclonal Antibody for IF-P, ELISA - P00450

Core Product Specifications and Parameters

Biological Background: Ceruloplasmin Function and Localization

• Ceruloplasmin is a multifunctional blue copper-binding glycoprotein containing 6-7 copper atoms per molecule.
• It exhibits ferroxidase activity, oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species, which is crucial for iron transport across cell membranes. Related references: PMID:16150804
• The enzyme also catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines like norepinephrine and serotonin. Related references: PMID:14623105 PMID:4643313 PMID:5912351
• It provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of heparan sulfate chains of GPC1 (By similarity).
• Ceruloplasmin possesses glutathione peroxidase-like activity, removing hydrogen peroxide and lipid hydroperoxide in the presence of thiols. Related references: PMID:10481051
• It acts as an inhibitor of the peroxidase activity of MPO (By similarity).
• Additionally, it shows NO-oxidase and NO2 synthase activities that help regulate endocrine NO homeostasis. Related references: PMID:16906150
• Ceruloplasmin is primarily expressed by the liver and secreted into plasma; it is a secreted glycoprotein with multiple disulfide bonds, repeated domains, and phosphorylation sites.

Experimental Guidance and Technical Tips

• As a rabbit polyclonal antibody, this product recognizes multiple epitopes; consider this advantage for detecting the target in various sample conditions.
• For immunofluorescence (IF-P) experiments, optimize fixation and permeabilization protocols suitable for secreted proteins.
• The immunogen corresponds to amino acids 680–790, a C-terminal region; validate detection of full-length ceruloplasmin in your ELISA setup.
• Cross-reactivity with mouse and rat suggests conserved epitopes; verify performance in the relevant species and tissue context.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves diagnostic manufacturers, labs, and research institutes with integrated access to IVD raw materials and technical support. This anti-Ceruloplasmin rabbit polyclonal antibody supports research into iron transport and oxidative stress. Beyond this product, CamelBio provides validated antibody pairs, optimized monoclonals and polyclonals, bulk ancillary reagents, and custom sourcing for rare targets—all designed to streamline your development workflow.