Anti-CDSN Rabbit Polyclonal Antibody for WB, ELISA - Q15517

Core Product Specifications and Parameters

Biological Background: CDSN Function and Localization

• Corneodesmosin (CDSN), also known as S protein, is a glycoprotein exclusively expressed in the skin.
• It plays a critical role in maintaining the integrity of the epidermal barrier.
• CDSN is a secreted protein that localizes to the extracellular space within the epidermis.
• The protein is subject to proteolytic processing and is a member of the reference proteome.
• Mutations in CDSN are associated with hypotrichosis, highlighting its importance in hair follicle biology.
• As a secreted signal peptide-containing protein, CDSN participates in corneocyte adhesion and desquamation.

Experimental Guidance and Technical Tips

• Based on the immunogen design (synthetic peptide within amino acids 100-200), this antibody likely recognizes an internal epitope common to human, mouse, and rat CDSN. Validate specificity in the relevant species.
• For Western blot, consider using reducing conditions and anti-rabbit secondary detection; expected band around 52 kDa. Include positive controls from skin tissue lysates.
• For ELISA, pair with a detection antibody targeting a non-overlapping epitope if developing a sandwich assay; optimize coating and blocking conditions.
• Due to exclusive skin expression, background may be higher in non-skin samples; ensure proper negative controls.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and research labs with a comprehensive portfolio of IVD raw materials. Our anti-CDSN rabbit polyclonal antibody is an excellent choice for epidermal barrier and skin disease research applications. Leverage CamelBio’s sourcing capabilities for validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents to streamline your assay development.