Anti-CDKN2D Polyclonal Antibody for WB, IF/ICC, ELISA - P55273

Core Product Specifications and Parameters

Biological Background: CDKN2D Function and Localization

• CDKN2D, also known as p19-INK4d, is a member of the INK4 family of cyclin-dependent kinase inhibitors.
• It functions as a tumor suppressor by strongly interacting with and inhibiting CDK4 and CDK6, thereby regulating cell cycle progression.
• The protein contains ANK repeats, which are important for protein-protein interactions.
• CDKN2D localizes to both the nucleus and cytoplasm, as supported by subcellular localization data.
• Post-translational modifications include acetylation, identified through direct protein sequencing and proteomics.
• Additional keywords: 3D-structure, reference proteome, repeat.

Experimental Guidance and Technical Tips

• This polyclonal antibody, raised against the full-length recombinant human CDKN2D protein, may be suitable for detecting CDKN2D in Western blot (WB) assays; consider optimizing detection conditions for your specific samples.
• For immunofluorescence/immunocytochemistry (IF/ICC), validate the antibody's ability to recognize endogenous CDKN2D in fixed cells and confirm appropriate subcellular localization.
• In ELISA applications, use appropriate controls and consider possible cross-reactivity with other INK4 family members, given the conserved domains.
• Since the immunogen covers the entire protein, the antibody may recognize multiple epitopes; consider this when interpreting results.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a one-stop sourcing partner for IVD raw materials, offering validated antibody pairs, optimized polyclonal antibodies, and bulk ancillary reagents. With this anti-CDKN2D antibody, researchers gain access to a key tool for cell cycle and tumor suppressor studies. CamelBio's comprehensive supply capabilities also include sourcing for rare target raw materials, streamlining your development from concept to clinic.