Anti-CDIP1 Rabbit Polyclonal Antibody for WB, ELISA - Q9H305

Core Product Specifications and Parameters

Biological Background: CDIP1 Function and Localization

• CDIP1, also known as LITAFL or C16orf5, is a p53/TP53-target protein that acts as a crucial apoptotic effector, particularly in TNF-mediated apoptosis.
• The protein is a transmembrane member of the LITAF-like family, sharing structural similarity with lipopolysaccharide-induced tumor necrosis factor-alpha factor.
• It localizes primarily to the membranes of late endosomes and lysosomes.
• CDIP1 is highly expressed in the brain, with lower levels in heart, skeletal muscle, kidney, pancreas, and liver.
• The protein contains zinc-binding motifs, suggesting metal-ion coordination may be important for its function.
• Alternative splicing produces multiple isoforms of CDIP1, as indicated by proteomics identification and reference proteome annotations.

Experimental Guidance and Technical Tips

• The immunogen was designed as a synthetic peptide from the central region (aa 100-200) of human CDIP1, targeting a conserved sequence that likely recognizes both human and predicted mouse/rat forms, supporting cross-reactivity.
• Given its transmembrane and endo-lysosomal localization, consider using appropriate lysis buffers (e.g., RIPA) and sample preparation for WB to solubilize membrane proteins.
• For ELISA, ensure coating conditions are optimized for the peptide or recombinant protein, and validate in the relevant sample system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—from concept to clinic. Our CDIP1 rabbit polyclonal antibody supports apoptosis and cell death research, backed by our extensive portfolio of validated antibody pairs, optimized polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing. Let us be your strategic partner in accelerating assay development.