Anti-CDH19 Rabbit Polyclonal Antibody for WB, ELISA - Q9H159

Core Product Specifications and Parameters

Biological Background: Cadherin-19 Function and Localization

• Cadherin-19, encoded by the CDH19 gene (also designated CDH7L2), is a calcium-dependent cell adhesion protein belonging to the cadherin superfamily.
• It preferentially mediates homophilic cell-cell adhesion, contributing to the sorting and segregation of heterogeneous cell types.
• The protein is a single-pass transmembrane glycoprotein with multiple extracellular cadherin repeat domains.
• Subcellularly, cadherin-19 is localized to the cell membrane, consistent with its adhesive function.
• It is broadly expressed in many tissues, with the notable exception of the uterus.
• The protein binds calcium ions, which are essential for its structural integrity and adhesive activity.
• Post-translational modifications include cleavage on pairs of basic residues and N-linked glycosylation.
• Alternative splicing generates multiple isoforms, as indicated by UniProt keywords.

Experimental Guidance and Technical Tips

• The immunogen (amino acids 240–440) corresponds to an internal region; thus, the antibody is likely to recognize both denatured and native forms of cadherin-19.
• For Western blotting, standard reducing SDS-PAGE conditions are recommended; expect a band near 87 kDa.
• In ELISA, consider using recombinant human CDH19 protein or lysates from human cell lines expressing the target.
• As a polyclonal antibody, it may exhibit slight lot-to-lot variability; validate in the relevant human sample system and consider knockout or knockdown controls for specificity confirmation.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio streamlines IVD raw-material procurement for diagnostic developers, offering this anti-CDH19 antibody as part of a broader portfolio that includes validated antibody pairs, monoclonal/polyclonal antibodies, and bulk ancillary reagents. Whether you need consistent materials for cell adhesion research or are scaling up assay production, CamelBio serves as a single-point supplier, also sourcing rare-target reagents to accelerate your workflow from concept to clinic.