Anti-CDH11 Polyclonal Antibody for WB, ELISA - P55287

Core Product Specifications and Parameters

Biological Background: CDH11 Function and Localization

• CDH11 encodes Cadherin-11, also known as OB-cadherin or OSF-4, a member of the cadherin family of calcium-dependent cell adhesion proteins.
• It mediates homophilic cell-cell adhesion, contributing to the sorting of heterogeneous cell types.
• CDH11 is required for proper focal adhesion assembly and regulates cell migration (PubMed:33811546). Related references: PMID:33811546
• It localizes to the cell membrane and is a single-pass type I transmembrane protein.
• Expressed mainly in the brain, with notable expression in embryonic facial mesenchyme, including palatal and dental mesenchyme (PubMed:33811546).
• The protein undergoes post-translational modifications such as glycosylation and phosphorylation, and features alternative splicing.
• Associated with diseases including deafness and intellectual disability, highlighting its developmental importance.

Experimental Guidance and Technical Tips

• Consider using the immunogen region (amino acids 120-400) for antibody specificity verification in your assays.
• Validate the antibody's performance in the relevant sample system, such as brain lysates for Western blot, given the tissue expression profile.
• For ELISA applications, pairing with a monoclonal antibody may enhance detection sensitivity and specificity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive partner for diagnostic manufacturers, labs, and research institutes, offering one-stop access to IVD raw materials, technical services, and consulting. This CDH11 polyclonal antibody supports research into cell adhesion and migration, and CamelBio can supply validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing to accelerate your projects from concept to clinic.