Anti-CD96/TACTILE Rabbit Monoclonal Antibody for FC, ELISA - Q3U0X8

Core Product Specifications and Parameters

Biological Background: CD96/TACTILE Function and Localization

• CD96, also known as Tactile or T cell-activated increased late expression protein, is a T-cell surface protein belonging to the immunoglobulin superfamily.
• It is implicated in adhesive interactions of activated T and NK cells during the late phase of the immune response.
• CD96 promotes NK cell-target adhesion by interacting with poliovirus receptor (PVR/CD155) present on target cells.
• The protein is a single-pass type I membrane protein, localized at the cell membrane.
• It features immunoglobulin-like domains, a signal peptide, disulfide bonds, glycosylation sites, and a transmembrane helix.
• CD96 may function after integrin- and selectin-mediated transendothelial migration, facilitating engagement with diseased cells within inflammatory sites (By similarity).
• The molecular weight of the mature protein is approximately 67 kDa, consistent with its glycoprotein nature.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the extracellular region (amino acids 35-536), covering the majority of the ectodomain, which is expected to recognize the native protein on cell surfaces, making it suitable for flow cytometry.
• For ELISA, consider using the recombinant protein as a positive control or coating antigen.
• Optimal antibody dilution and incubation conditions should be determined experimentally for each application.
• Ensure appropriate isotype controls are used in flow cytometry experiments.
• The antibody specifically recognizes mouse CD96; cross-reactivity with other species has not been determined.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and researchers with comprehensive access to IVD raw materials, including validated antibody pairs, monoclonal antibodies, and ancillary reagents. Our CD96/TACTILE rabbit monoclonal antibody exemplifies our commitment to supplying high-quality tools for immune cell adhesion and signaling studies. Partner with CamelBio to streamline your sourcing of rare and standard targets, from early development to clinical application.